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| ID: | 513 | | Title: | NK cell compartment in patients with coronary heart disease - http://www.immunityageing.com/content/4/1/3 | | Description: | Background:
Viral and bacterial infections have been considered as a risk factor for Coronary Heart Disease (CHD). NK cells, as a first line of defense against those infections, may play a role in CHD development. Thus, the main aim of our study was to determine NK cell compartment in patients with CHD undergoing coronary artery by-pass grafting.
Results:
Ninety three patients with CHD were included into the study; the control group consisted of 49 healthy volunteers. As compared to controls, CHD patients had lower NK cytotoxic activity. CHD group had also a decreased absolute number and percentage of total NK cells and CD3-CD56dim cytotoxic NK subset. In addition, we observed tendency toward lower percentage of the CD3-CD56bright regulatory NK subset and CD3-CD56+IFN-γ+ cells in CHD patients.
Conclusion:
These data indicate that CHD is associated with an impairment of NK cells compartment. | | Category: | Aging | | Link Owner: | | | Date Added: | | | Number Hits: | 0 | | |
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